Mr. Voldemort in the dining room with a wand...I'm not one of those folks that pores over the Leaky Cauldron or mugglenet boards trying to piece together clues about who's going to die (and who would be mortified if anyone actually told them) but I do have my theory. And I should warn you that the two characters I said were most likely to get it in Serenity were the ones that got it, so take that for what it's worth.
I'm betting that Rubeus Hagrid and Neville Longbottom don't survive the Deathly Hallows. I'm guessing that Neville manages to off Bellatrixie (if any of the kids can muster up enough hate to utter an Unforgivable Curse, he can) and then goes down to He-Who-Must-Not-Be-Named before Harry finally morts Voldie. As for Hagrid, every other father figure Harry has had has died so I'm guessing Hagrid will bite it too. But I'm still not convinced that we won't see Dumbledore again before we're done.
So there - not spoilers because I have absolutely no way of knowing any of this but I figured it was only fair to throw my predictions out there to be scoffed at or wondered over a few days from now.
We're debating on whether to go ahead and buy two copies or just one. We didn't preorder any but we've never had any trouble picking up a Potter within 24 hours of release, so hopefully that will hold true again. Until we're both through, this will be a Potter-free zone...